Histopathological Identification of Colon Cancer with Microsatellite Instability
โ Scribed by Julian Alexander; Toshiaki Watanabe; Tsung-Teh Wu; Asif Rashid; Shuan Li; Stanley R. Hamilton
- Book ID
- 117021986
- Publisher
- American Society for Investigative Pathology
- Year
- 2001
- Tongue
- English
- Weight
- 724 KB
- Volume
- 158
- Category
- Article
- ISSN
- 0002-9440
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Microsatellite instability (MSI) is intrinsic to most colorectal carcinomas (CRC) from patients with hereditary nonpolyposis colorectal cancer (HNPCC), reflecting germline mutations in the mismatch-repair (MMR) genes. Its occurrence and chronological sequence of development in sporadic CRC appears l
## Abstract Colon cancers with microsatellite instability (MSI) demonstrate a host immune response characterized by tumor infiltrating lymphocytes (TILs) that may exert effects upon tumor cell apoptosis and cell proliferation. Accordingly, we compared rates of apoptosis and cell proliferation in co