Histopathological features of breast cancer in carriers of ATM gene variants
β Scribed by R L Balleine; R Murali; A M Bilous; G Farshid; P Waring; P Provan; K Byth; H Thorne; kConFab Investigators; J A Kirk
- Book ID
- 108780225
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 142 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0309-0167
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Epidemiological studies have shown an increased risk of breast cancer in obligate ataxia telangiectasia (A-T) heterozygotes. We analyzed 100 samples from young breast cancer patients for mutations in ataxia-telangiectasia mutated (ATM), the gene responsible for the autosomal recessive condition, A-T
## Abstract It has been proposed that women carrying heterozygous mutations of the __ATM__ gene could be at increased risk of developing breast cancer. However, data in the literature are contrasting and no firm conclusion has been reached. Our aim was to verify whether __ATM__ inactivation could p