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Histopathologic validation of the sentinel node concept in oral and oropharyngeal squamous cell carcinoma

✍ Scribed by Eline J. C. Nieuwenhuis; Isaac van der Waal; C. René Leemans; Alain Kummer; Rik Pijpers; Jonas A. Castelijns; Ruud H. Brakenhoff; Gordon B. J. Snow

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
256 KB
Volume
27
Category
Article
ISSN
1043-3074

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✦ Synopsis

Background. In patients with head and neck squamous cell carcinoma (HNSCC), the presence of lymph node metastases is the most important prognosticator. Sentinel node (SN) biopsy has been shown to be an accurate staging technique for patients with breast cancer and melanoma and might also be suited for patients with HNSCC. This study was undertaken to determine whether the SN concept holds true for HNSCC and could be exploited for SN biopsy.

Methods. In 22 patients with T2 to T4 N0 oral or oropharyngeal squamous cell carcinoma (SCC) who were scheduled to undergo combined primary tumor excision and elective unilateral (n = 17) or bilateral (n = 5) neck dissection, SN identification was performed the day before surgery by use of lymphoscintigraphy after peritumoral injections of 99m Tc-labeled colloidal albumin. After the neck dissection specimens were removed, all SNs, all other radioactive lymph nodes, and all nonradioactive lymph nodes were retrieved for histopathologic analysis,

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