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✦   LIBER   ✦

Histopathologic risk factors in retinoblastoma: A retrospective study of 172 patients treated in a single institution

✍ Scribed by Fatima Khelfaoui; Pierre Validire; Anne Auperin; Erica Quintana; Jean Michon; Hélène Pacquement; Laurence Desjardins; Bernard Asselain; Pierre Schlienger; Philippe Vielh; Jean-Louis Dufier; Jean-Michel Zucker; François Doz


Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
742 KB
Volume
77
Category
Article
ISSN
0008-543X

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✦ Synopsis


BACKGROUND. Microscopic extrascleral involvement and involvement of optic nerve resection line are accepted risk factors for orbital andlor metastatic disease from retinoblastoma. Conversely, choroidal and retrolaminar optic nerve involvement are questionable risk factors. The aim of this retrospective study was to define the histopathologic risk factors for orbital andlor metastatic disease in patients treated by first-line enucleation.

MEMODS.

Histopathologic review of 172 evaluable patients treated at lnstitut Curie between 1977 and 1990 determined the degree of choroidal (minimal or massive), scleral (intra-or extrascleral), optic nerve (prelaminar, retrolaminar with or without resection line involvement). and anterior chamber invasion. The degree of differentiation was also analyzed. The log rank test was used for univariate analysis and the Cox regression model was used for multivariate analysis.


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