Histopathologic findings predicting lymph node metastasis and prognosis of patients with superficial esophageal carcinoma : Analysis of 240 surgically resected tumors
✍ Scribed by Yusuke Tajima; Yukihiro Nakanishi; Atsushi Ochiai; Yuji Tachimori; Hoichi Kato; Hiroshi Watanabe; Hajime Yamaguchi; Kimio Yoshimura; Mitsuo Kusano; Tadakazu Shimoda
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 390 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
BACKGROUND.
If it were possible to elucidate the histopathologic findings predicting lymph node metastasis and prognosis in superficial squamous cell carcinoma of the esophagus (SSCCE), they could be used as markers to identify patients who do not require additional surgical resection after endoscopic mucosal resection (EMR).
METHODS.
Two hundred forty surgically resected SSCCEs were examined histopathologically. Histopathologic factors including vertical tumor invasion depth in the submucosal layer (VTIDsm), degree of nuclear atypia (low, one point; high, two points), growth pattern (expansive, one point; infiltrative, two points), and histologic grade (calculated by adding the latter two scores to obtain Grade 1, two points; Grade 2, three points; and Grade 3, four points) were evaluated to investigate the associations among these factors, lymph node metastasis, and prognosis.
OR: odds ratio