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Histone gene expression remains coupled to DNA synthesis during in vitro cellular senescence

โœ Scribed by Gerard Zambetti; Robert Dell'Orco; Gary Stein; Janet Stein


Book ID
115892236
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
555 KB
Volume
172
Category
Article
ISSN
0014-4827

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Transcriptional activation of c-fos in response to both serum stimulation and D N A damage requires the serum response element. The inability of in vitro aged or senescent fibroblasts to proliferate in response to serum has been shown to be associated with repressed c-fos expression and reduced AP-1