Histone deacetylases and repression of the gonadotropin genes
β Scribed by Philippa Melamed
- Book ID
- 116909111
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 641 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1043-2760
No coin nor oath required. For personal study only.
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## Abstract __ARHI__ is a maternally imprinted tumor suppressor gene that is expressed in normal breast and ovarian epithelial cells but not in most breast and ovarian cancers. Our earlier studies showed that histone deacetylases (HDACs) in complexes with transcription factors E2F1 and E2F4 play an
## Abstract Histone deacetylases (HDACs) modulate the transcription of a subset of genes by various means. HDAC5 is a class II HDAC whose subcellular location is signalβdependent. At present, its known gene targets are few in number. Here we identify a new HDAC5 target: the gene encoding the cell c