Histone deacetylase inhibitors augment doxorubicin-induced DNA damage in cardiomyocytes

Histone deacetylase inhibitors FK228, N-

Histone deacetylase inhibitors FK228, N-(2-aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)amino- methyl]benzamide and m-carboxycinnamic acid bis-hydroxamide augment radiation-induced cell death in gastrointestinal adenocarcinoma cells

✍ Yubin Zhang; Masaaki Adachi; Xudong Zhao; Rina Kawamura; Kohzoh Imai 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 466 KB

## Abstract HDAC inhibitors induce histone hyperacetylation by a relative increase of histone acetyltransferase activity. Histone hyperacetylation may affect chromatin structure and susceptibility to DNA‐damaging stress, such as IR. We here investigate whether these inhibitors can radiosensitize hu