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Histone deacetylase inhibitors as therapeutics for polyglutamine disorders

โœ Scribed by Butler, Rachel; Bates, Gillian P.


Book ID
109962295
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
621 KB
Volume
7
Category
Article
ISSN
1471-0048

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## Abstract In cancer cells, an imbalance often exists between histone acetyltransferase (HAT) and histone deacetylase (HDAC) activities, and various drug companies are actively seeking competitive HDAC inhibitors for chemotherapeutic intervention. Cancer cells appear to be more sensitive than nont