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Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinoma

✍ Scribed by Junpei Yamaguchi; Motoko Sasaki; Yasunori Sato; Keita Itatsu; Kenichi Harada; Yoh Zen; Hiroko Ikeda; Yuji Nimura; Masato Nagino; Yasuni Nakanuma


Book ID
108586563
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
512 KB
Volume
101
Category
Article
ISSN
1347-9032

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## Abstract During tumorigenesis, cancer‐related genes can be silenced by aberrant DNA methylation and by changes in chromatin structure. It has been reported that 5‐aza‐2′‐deoxycytidine, a potent inhibitor of DNA methylation, in combination with histone deacetylase inhibitors, can produce a synerg