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Histone deacetylase 3 represses p15INK4b and p21WAF1/cip1 transcription by interacting with Sp1

✍ Scribed by Weifeng Huang; Dapeng Tan; Xiuli Wang; Songyan Han; Jiang Tan; Yanmei Zhao; Jun Lu; Baiqu Huang


Book ID
116291815
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
489 KB
Volume
339
Category
Article
ISSN
0006-291X

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Histone deacetylase inhibitor-induced expression of p21 WAF1 is p53 independent. In the present study, we provide evidence that trichostatin A (TSA), a specific inhibitor of histone deacetylase, can elevate H3 and H4 acetylation and p21 WAF1 expression in NIH3T3 cells at first. To identify the trans