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Histone ADP-ribosylation in DNA repair, replication and transcription

โœ Scribed by Simon Messner; Michael O. Hottiger

Book ID
113926697
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
475 KB
Volume
21
Category
Article
ISSN
0962-8924

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## Abstract Poly(ADPโ€ribosyl)ation is a postโ€translational modification occurring in the nucleus. The most abundant and bestโ€characterized enzyme catalyzing this reaction, poly(ADPโ€ribose) polymerase 1 (PARP1), participates in fundamental nuclear events. The enzyme functions as molecular โ€œnick sens