High levels of intracellular polyamines
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Cheryl A. Hobbs; Susan K. Gilmour
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Article
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2000
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John Wiley and Sons
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English
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Polyamines stimulate expression of a variety of genes, including many implicated in cell proliferation. Indeed, aberrant expression of ornithine decarboxylase (ODC), a rate-limiting enzyme in polyamine biosynthesis, plays a causal role in tumorigenesis. Gene activity is influenced by dynamic changes