Histomorphometric analysis following augmentation of the posterior mandible using cancellous bone-block allograft
✍ Scribed by Joseph Nissan; Vered Marilena; Ora Gross; Ofer Mardinger; Gavriel Chaushu
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 270 KB
- Volume
- 97A
- Category
- Article
- ISSN
- 1549-3296
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✦ Synopsis
Abstract
The present study was conducted to histologically and histomorphometrically evaluate the application of cancellous bone‐block allografts for the augmentation of the posterior atrophic mandible. Twenty‐four consecutive patients underwent augmentation with cancellous bone‐block allografts in the posterior mandible. A bony deficiency of at least 3 mm horizontally and/or vertically according to CT para‐axial reconstruction served as inclusion criteria. Following 6 months, 85 implants were placed and a cylindrical sample core was collected. All specimens were prepared for histological and histomorphometrical examination. Implant survival rate was 95.3%. Follow‐up ranged 12–66 months (mean 43 ± 19 months). The mean newly formed bone was 44 ± 28%, that of the residual cancellous bone‐block allograft 29 ± 24%, and of the marrow and connective tissue 27 ± 21%. Statistically significant histomorphometric differences regarding newly formed bone (69% vs. 31%, p = 0.05) were found between younger (<45 years) and older (>45 years) patients, respectively. Histomorphometric differences regarding residual cancellous bone‐block allograft (17% vs. 35%) and of the marrow and connective tissue (14% vs. 34%) were not statistically significant. Cancellous bone‐block allograft is biocompatible and osteoconductive, permitting new bone formation following augmentation of extremely atrophic posterior mandible with a two‐stage implant placement procedure. New bone formation was age‐dependent. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A: , 2011.