Histological necrosis in soft tissue sarcoma following preoperative irradiation

✍ Scribed by Lisa Hew; Rita Kandel; Aileen Davis; Dr. Robert Bell; Brian O'Sullivan; Charles Catton

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 428 KB
• Volume: 57
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930570208

✦ Synopsis

Forty-eight patients with soft tissue sarcomas that presented adverse fcatures for trcatment by limb salvage surgery and postoperative irradiation were treatcd by preoperative irradiation and surgery using a consistent protocol. Following resection, the extent of histological necrosis in the specimen was scored according to thc criteria of Willet et al. [ 11). Of the 48 cases, 16 (34%) demonstrated Grade I rcsponse ( -3 0 % necrosis), 15 (31%) Grade 2 (5040% necrosis), and 17 (35%) Grade 3 (>80% necrosis). There was a trend toward morc extensive necrosis in liposarcoma tumors (53% showing Grade 3 response compared to 26% of other sarcomas). Logistic regression analysis demonstrated a significant relationship between necrosis and tumor size (P <; 0.001) with larger tumors having higher grades of necrosis. Tumor gradc did not seein to affcct the extent of necrosis. In comparison to the previous report of necrosis in soft tissue sarcoma following irradiation 11 01, the current analysis revealed a smaller proportion of tumors with Grade 3 necrosis. Q IYW Wiby-Liss, Inc.