✦ LIBER ✦

Histologic differentiation and chemosensitivity of human head and neck squamous cell carcinomas

✍ Scribed by Dr. Tadashi Nakashima; Drs. Yoshihiko Maehara; Shunji Kohnoe; Itsuroh Hayashi; Yasaburoh Katsuta

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 392 KB
Volume: 12
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.2880120506

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The chemosensitivities of 42 human head and neck squamous cell carcinomas were examined using the in vitro succinate dehydrogenase inhibition (SDI) test. The tumor tissues obtained at surgery or biopsy were exposed to five different antitumor drugs: adriamycin (ADM), cisplatin (CDDP), carboquone (CQ), 5‐fluorouracil (5‐FU), and 1‐hexylcarbamoyl‐5‐fluorouracil (HCFU). The results were analyzed according to the histopathologic degree of differentiation of well, moderately, and poorly differentiated squamous cell carcinoma. The average decrease in succinate dehydrogenase activity was 43.2 /pm 24.9 for ADM, 29.0 /pm 14.2 for CDDP, 32.9 /pm 17.6 for CQ, 64.2 /pm 20.6 for 5‐FU, and 26.8 /pm 16.9 for HCFU. There was a statistically significant difference in the decrease of succinate dehydrogenase activity between well and poorly differentiated squamous cell carcinomas. These data suggest that, for patients with a poorly differentiated squamous cell carcinoma, the response to anticancer drugs may be more satisfactory than in those with a welldifferentiated squamous cell carcinoma.

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