Histocompatibility antigens in primary affective disorders

✍ Scribed by P. Zvolský; M. Dvořáková; A. Májský; K. Souček

• Book ID: 104731631
• Publisher: Springer-Verlag
• Year: 1978
• Tongue: English
• Weight: 181 KB
• Volume: 225
• Category: Article
• ISSN: 1433-8491
• DOI: 10.1007/bf00343399

✦ Synopsis

We determined 27 histocompatibility antigens of A, B, and C locus with a standard lymphocyte cytotoxicity test in 125 patients suffering from primary affective disorders, 77 of bipolar type, 24 of unipolar type, and 24 with schizo-affective psychosis. Comparison with a normal control group showed significant increases in the frequencies of antigens Bw40 and Cw4 in unipolar patients and a significantly decreased frequency of antigen Cw3 in bipolar patients. The statistical significances which were at the 5% level, disappeared when the P values were corrected for the number of antigens investigated. Our results failed to confirm previous findings of significantly altered antigen frequencies among patients with primary affective disorders.