Histiocytosis X: Clinical trial of chlorambucil: A report from childrens cancer study group

✍ Scribed by Lahey, M. E. ;Heyn, R. M. ;Newton, W. A. ;Shore, N. ;Smith, W. B. ;Leikin, S. ;Hammond, D.

• Publisher: John Wiley and Sons
• Year: 1979
• Tongue: English
• Weight: 366 KB
• Volume: 7
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/mpo.2950070302

✦ Synopsis

Abstract

A prospective study for histiocytosis X was designed to determine whether “good risk” patients, ie, those without evidence of dysfunction of liver, lung, or hemopoietic system, would respond to single agent therapy; in this case chlorambucil (CMB) used in a dose of 5 mgm/m^2^ /day. If there was no response after an adequate trial period, treatment was initiated with four drugs using a combination of prednisone, vinblastine, cyclophosphamide and methotrexate. There were 26 evaluable patients, 57% of whom were less than two years of age at onset of therapy. There were three complete and four partial responses to CMB for a response rate of 26.9%. Sixteen patients received an adequate trial of four‐drug therapy with three complete and two partial responses for a response rate of 33%. These responses were inferior to those previously reported for either single agents or combined therapy in histiocytosis X.