Histidyl-tRNA synthetase of Chinese hamster ovary cells contains phosphoserine
β Scribed by Steven C. Gerken; Irene L. Andrulis; Stuart M. Arfin
- Book ID
- 113266344
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 223 KB
- Volume
- 869
- Category
- Article
- ISSN
- 0167-4838
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In Chinese hamster ovary cells, histidine starvation and inactivation of histidyl-tRNA synthetase by mutations or histidinol result in stimulation of protein breakdown. We have previously shown that the regulatory mechanism recognizes the level of aminoacylation of tRNAH'>. We now report that it is
## Abstract A preliminary investigation was carried out to determine how conditional lethal mutants affected in particular aminoacylβtRNA synthetases may be used to study the role of tRNA charging levels in protein synthesis. The relationship between rate of protein synthesis and level of histidylβ