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Histidine-rich Glycoprotein Binds Fibrin(ogen) with High Affinity and Competes with Thrombin for Binding to the '-Chain

✍ Scribed by Vu, T. T.; Stafford, A. R.; Leslie, B. A.; Kim, P. Y.; Fredenburgh, J. C.; Weitz, J. I.


Book ID
119940917
Publisher
The American Society for Biochemistry and Molecular Biology
Year
2011
Tongue
English
Weight
522 KB
Volume
286
Category
Article
ISSN
0021-9258

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P-glycoprotein (P-gp) is a plasma membrane glycoprotein that confers multidrug resistance on cells by virtue of its ability to exclude cytotoxic drugs in an ATP-dependent manner. The most commonly considered hypothesis is that P-gp acts as an ATP-driven drug-export pump, the mechanism of which is no