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Histaminergic modulation and chemically-induced seizures in mice

✍ Scribed by G. Sturman; P. Freeman


Publisher
SP Birkhäuser Verlag Basel
Year
1992
Tongue
English
Weight
184 KB
Volume
36
Category
Article
ISSN
1420-908X

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Seizures induced by aminooxyacetic acid
✍ Dr. Waldemar A. Turski; Marek Dziki; Ewa Urbanska; Lineu S. Calderazzo-Filho; Es 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 866 KB

Systemic (s.c.) administration of aminooxyacetic acid (AOAA) in mice triggered clonic convulsions with a CD50 (convulsive dose) of 68 mgkg (range 54-86). AOAA also induced clonic convulsions in mice subjected to intracerebroventricular administration of the drug with a CD50 of 0.04 pmol (range 0.028