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Histamine promotes excitability in bovine adrenal chromaffin cells by inhibiting an M-current

✍ Scribed by Damian J. Wallace; Chen Chen; Philip D. Marley


Book ID
110111584
Publisher
Cambridge University Press
Year
2002
Tongue
English
Weight
777 KB
Volume
540
Category
Article
ISSN
0022-3751

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We investigated the effects of amitriptyline, a tricyclic antidepressant, on [3H]norepinephrine ([3H]NE) secretion and ion flux in bovine adrenal chromaffin cells. Amitriptyline inhibited [3H]NE secretion induced by 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP) and 70 mM K+. The half maximal inhib