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Histamine N-methyltransferase in humans tissues: inhibition fey chloroquine

✍ Scribed by G.M. Pacifici; P. Donatelli; L. Giuliani

Book ID
115883783
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
105 KB
Volume
183
Category
Article
ISSN
0014-2999

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πŸ“œ SIMILAR VOLUMES

Stereoselective inhibition by chloroquin
Stereoselective inhibition by chloroquine of histamine N-methyltransferase in the human liver and brain
✍ P. Donatelli; G. Marchi; G. M. Pacifici; L. Giuliani; L. L. Gustafsson πŸ“‚ Article πŸ“… 1994 πŸ› Springer 🌐 English βš– 421 KB

This study was designed to determine whether both enantiomers of chloroquine inhibit histamine N-methyltransferase. The mean estimates of ICs0 for the d-and/-enantiomers of chloroquine were 4.9 and 17.8 ~tM (liver), respectively and 6.9 and 21.6 ~tM (brain), respectively. K i estimates were signific