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Histamine Enhances the Production of Granulocyte-Macrophage Colony-Stimulating Factor via Protein Kinase Calpha and Extracellular Signal-Regulated Kinase in Human Keratinocytes

✍ Scribed by Kanda, Naoko; Watanabe, Shinichi

Book ID: 110733144
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 392 KB
Volume: 122
Category: Article
ISSN: 0022-202X
DOI: 10.1111/j.0022-202x.2004.22432.x

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## Abstract Blood vessel injury results in limited oxygen tension and diffusion leading to hypoxia, increased anaerobic metabolism, and elevated production of acidic metabolites that cannot be easily removed due to the reduced blood flow. Therefore, an acidic extracellular pH occurs in the local mi