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Hippocampal volumetrics in depression: The importance of the posterior tail

✍ Scribed by Jerome J. Maller; Z. Jeff Daskalakis; Paul B. Fitzgerald

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
174 KB
Volume
17
Category
Article
ISSN
1050-9631

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✦ Synopsis

Abstract

Studies of patients with major depression disorder (MDD) have revealed reduced hippocampal volumes, but findings have been inconsistent due to sample and measurement differences. The current study sought to measure this structure in a large sample of MDD and control subjects, using a strict measurement protocol, in order to elucidate morphological‐specific volumetric differences. Forty‐five subjects with treatment‐resistant MDD and 26 controls underwent psychiatric assessments and brain magnetic resonance imaging (MRI). The findings of this study indicate that (1) MDD results in reduced hippocampal volume, particularly in the tail section, (2) region of interest (ROI) estimation protocols and sample characteristics may help explain volumetric differences between previous MDD studies, and (3) specific ROI atrophy in treatment‐resistant depression is influenced by sex. © 2007 Wiley‐Liss, Inc.

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