✦ LIBER ✦

Hippocampal PET activations of memory encoding and retrieval: The HIPER model

✍ Scribed by Martin Lepage; Reza Habib; Endel Tulving

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 198 KB
Volume: 8
Category: Article
ISSN: 1050-9631
DOI: 10.1002/(sici)1098-1063(1998)8:4<313::aid-hipo1>3.0.co;2-i

No coin nor oath required. For personal study only.

✦ Synopsis

A meta-analysis of experimentally induced changes in blood flow ("activations") in positron emission tomography (PET) studies of memory has revealed an orderly functional anatomic pattern: Activations in the hippocampal region associated with episodic memory encoding are located primarily in the rostral portions of the region, whereas activations associated with episodic memory retrieval are located primarily in the caudal portions. These findings are based on an analysis of a sample of 54 "hippocampal encoding and retrieval" activations that were culled from an overall database consisting of 52 published PET studies of memory. We refer to this general pattern of rostrocaudal gradient of encoding and retrieval PET activations as the HIPER (Hippocampal Encoding/Retrieval) model. The model suggests a division of memory-related labor between the rostral and caudal portions of the hippocampal formation. Because functional anatomic pattern of encoding and retrieval activation that defines the HIPER model was unprecedented and unexpected, it is difficult to relate the model to what is already known or thought about functional neuroanatomy of episodic memory in the hippocampal regions. The model is interesting primarily because its exploration may yield fresh insights into the neural basis of human memory.

📜 SIMILAR VOLUMES

Regional analysis of hippocampal activat

Regional analysis of hippocampal activation during memory encoding and retrieval: fMRI study

✍ Michael D. Greicius; Ben Krasnow; Jesse M. Boyett-Anderson; Stephan Eliez; Alan 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 491 KB

Investigators have recently begun to examine the differential role of subregions of the hippocampus in episodic memory. Two distinct models have gained prominence in the field. One model, outlined by Moser and Moser (Hippocampus 1998;8:608-619), based mainly on animal studies, has proposed that epis

Medial temporal lobe activations in fMRI

Medial temporal lobe activations in fMRI and PET studies of episodic encoding and retrieval

✍ Daniel L. Schacter; Anthony D. Wagner 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 308 KB 👁 2 views

Early neuroimaging studies often failed to obtain evidence of medial temporal lobe (MTL) activation during episodic encoding or retrieval, but a growing number of studies using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) have provided such evidence. We review

Encoding and retrieval in a model of the

Encoding and retrieval in a model of the hippocampal CA1 microcircuit

✍ Vassilis Cutsuridis; Stuart Cobb; Bruce P. Graham 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 965 KB

## Abstract It has been proposed that the hippocampal theta rhythm (4–7 Hz) can contribute to memory formation by separating encoding (storage) and retrieval of memories into different functional half‐cycles (Hasselmo et al. (2002) Neural Comput 14:793–817). We investigate, via computer simulations

Encoding and retrieval of episodic memor

Encoding and retrieval of episodic memories: Role of cholinergic and GABAergic modulation in the hippocampus

✍ Michael E. Hasselmo; Bradley P. Wyble; Gene V. Wallenstein 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 283 KB 👁 2 views

This research focuses on linking episodic memory function to the cellular physiology of hippocampal neurons, with a particular emphasis on modulatory effects at cholinergic and g g-aminobutyric acid B receptors. Drugs which block acetylcholine receptors (e.g., scopolamine) have been shown to impair

Sustained dorsal hippocampal activity is

Sustained dorsal hippocampal activity is not obligatory for either the maintenance or retrieval of long-term spatial memory

✍ Nicola J. Broadbent; Larry R. Squire; Robert E. Clark 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 520 KB

## Abstract Memories are initially stored in a labile state and are subject to modification by a variety of treatments, including disruption of hippocampal function. We infused a sodium channel blocker (or CNQX) to inactivate the rat dorsal hippocampus reversibly for 1 week following training on a

Influence of predator stress on the cons

Influence of predator stress on the consolidation versus retrieval of long-term spatial memory and hippocampal spinogenesis

✍ David M. Diamond; Adam M. Campbell; Collin R. Park; James C. Woodson; Cheryl D. 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 269 KB

We have studied the influence of predator stress (30 min of cat exposure) on long-term (24 h) spatial memory and the density of spines in basilar dendrites of CA1 neurons. Predator stress occurred either immediately before water maze training (Stress Pre-Training) or before the 24 h memory test (Str