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Hippocampal Glycogen Synthase Kinase 3β is Critical for the Antidepressant Effect of Cyclin-Dependent Kinase 5 Inhibitor in Rats

✍ Scribed by Li, Gang; Liu, Ting; Kong, Xiangqian; Wang, Lei; Jin, Xing


Book ID
121545406
Publisher
Humana Press Inc
Year
2014
Tongue
English
Weight
354 KB
Volume
54
Category
Article
ISSN
0895-8696

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## Abstract Excitotoxicity and cell death induced by glutamate are involved in many neurodegenerative disorders. We have previously demonstrated that excitotoxicity induced by millimolar concentrations of glutamate in hippocampal slices involves apoptotic features and glutamate‐induced glutamate re