This study was undertaken to compare the effect of hippocampal neurotoxic lesions in rats on two behavioral tasks, one a test of spatial learning, and the other an operant discrimination task that is acquired by forming nonspatial configural associations. Lesions of the hippocampus were made with mi
Hippocampal endocannabinoids inhibit spatial learning and limit spatial memory in rats
β Scribed by Lianne Robinson; Susan McKillop-Smith; Nicola L. Ross; Roger G. Pertwee; Robert E. Hampson; Bettina Platt; Gernot Riedel
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 510 KB
- Volume
- 198
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Recent studies show that baclofen, a selective GABA B agonist, impairs different kinds of learning. In the present study we investigated the effect of microinfused baclofen into the hippocampus of male Wistar rats, on the performance in the Morris water maze. Rats of 8-10 weeks of age were implanted
## Abstract Kindling with electrical stimulation of the dorsal hippocampus has been shown to disrupt spatial task performance in rats. The present study investigated the specificity of this effect in terms of the possible contribution of nonmnemonic effects, the presence of a more general mnemonic
## Abstract Memory consolidation in mammalian brain is accompanied by widespread reorganization of synaptic contacts and dendritic structure. Understanding of the proteinβprotein interactions that underlie these structural changes has been hampered by the difficulty of studying proteinβprotein inte
This study examined learning about the spatial environment by rats during a single 10 min period of exploration on an eight-arm radial maze. Because no specific behaviors were learned during this procedure, the existence of learned spatial information was inferred from its retarding effect on subseq