Hippocampal dentate granule cell degeneration after adrenalectomy in the rat is not reversed by dexamethasone

Adrenalectomy-induced granule cell degen

Adrenalectomy-induced granule cell degeneration in the hippocampus causes spatial memory deficits that are not reversed by chronic treatment with corticosterone or fluoxetine

✍ Simon C. Spanswick; Jonathan R. Epp; Julian R. Keith; Robert J. Sutherland 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 772 KB

## Abstract Long‐term adrenalectomy (ADX) causes a nearly complete and selective loss of granule cells in the dentate gyrus (DG) of the hippocampus. Previously, learning and memory deficits have been observed following ADX‐induced granule cell degeneration for tasks that require the hippocampus. Ou