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High–resolution crystal structure of deoxy hemoglobin complexed with a potent allosteric effector

✍ Scribed by Martin K. Safo; Carmen M. Moure; James C. Burnett; Gajanan S. Joshi; Donald J. Abraham

Book ID
111753469
Publisher
Cold Spring Harbor Laboratory Press
Year
2001
Tongue
English
Weight
437 KB
Volume
10
Category
Article
ISSN
0961-8368

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Coumarin antibiotics, such as clorobiocin, novobiocin, and coumermycin A1, inhibit the supercoiling activity of gyrase by binding to the gyrase B (GyrB) subunit. Previous crystallographic studies of a 24-kDa Nterminal domain of GyrB from E. coli complexed with novobiocin and a cyclothialidine analog