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Highly stereoselective transformation of (1S,3S)-cis-1,3-disubstituted tetrahydro-β-carbolines into (1S,3R)-trans-1,3-disubstituted tetrahydro-β-carbolines: an improved asymmetric synthesis of tadalafil from l-tryptophan

✍ Scribed by Dong, Jing; Meng, Tian-Zhuo; Shi, Xiao-Xin; Zou, Wen-Hui; Lu, Xia


Book ID
120935011
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
649 KB
Volume
24
Category
Article
ISSN
0957-4166

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Enantiospecific Formation of trans-1,3-Disubstituted Tetrahydro-βcarbolines by the Pictet-Spengler Reaction and Conversion of cis Diastereomers into Their trans Counterparts by Scission of the C-1/N-2 Bond. -The factors which effect the stereoselective formation of trans-products in the Pictet-Spen