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Highly stereoselective synthesis of vitamin A and all-trans retinoic acid by low-valent Titanium induced reductive elimination

✍ Scribed by Guy Solladié; André Girardin

Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
183 KB
Volume
29
Category
Article
ISSN
0040-4039

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✦ Synopsis

Appllcatlon of the low-valent Titanium induced reductive elimlnatron gave a new and highly stereoselectlve approach to Vitamin A and all-trans retlnolc acid. Since the first industrial synthesis of Vitamin A reported by Isler' at Hoffmann La , Roche in 1947, many papers describing different approaches appeared'. The BASF industrial preparation3 of all-trans retinolc acid featured Wittig condensations,

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