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Highly Stereoselective Reductions of α-Alkyl-1,3-diketones and α-Alkyl-β-keto Esters Catalyzed by Isolated NADPH-Dependent Ketoreductases

✍ Scribed by Kalaitzakis, Dimitris; Rozzell, J. David; Kambourakis, Spiros; Smonou, Ioulia


Book ID
120269497
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
52 KB
Volume
7
Category
Article
ISSN
1523-7060

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A highly efficient and stereoselective technique for additions to syn-β-alkyl-β-hydroxy-α-methyl ketones is now available. The methodology is based on the conversion of the starting material into a trichlorotitanium alkoxide derivative, which is able to assume a stable cyclic arrangement exhibiting