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Highly stereocontrolled syntheses of 2,3-disubstituted 1,4-butyrolactones using ionic and free radical reactions

✍ Scribed by Hanessian, Stephen; Vanasse, Benoit; Yang, Hua; Alpegiani, Marco


Book ID
111859075
Publisher
NRC Research Press
Year
1993
Tongue
French
Weight
171 KB
Volume
71
Category
Article
ISSN
0008-4042

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✍ Schick, Hans ;Roatsch, Birgit ;Schwarz, Hartmut ;Hauser, André ;Schwarz, Sigfrid 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 453 KB 👁 1 views

## Abstract In contrast to earlier reported unsuccessful experiments the Michael addition of prop‐2‐enal to 2‐methylcyclopentane‐1,3‐dione (1) affords 3‐(1‐methyl‐2,5‐dioxocyclopentyl)propanal (3) in 90% yield, if the reaction is carried out in water without a basic catalyst. This aldehyde is conve