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Highly sensitive determination of saquinavir in biological samples using liquid chromatography–tandem mass spectrometry

✍ Scribed by Jürgen Burhenne; Klaus-Dieter Riedel; Meret Martin-Facklam; Gerd Mikus; Walter E Haefeli

Book ID
108497414
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
460 KB
Volume
784
Category
Article
ISSN
1873-376X

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## Abstract Sphingosine kinase (SphK) is a key enzyme in modulating the levels of sphingosine 1‐phosphate (S1P) as well as an important enzyme in numerous biological responses. Using C17‐sphingosine as a substrate, we established a rapid, sensitive and highly efficient method for determination of S