Highly selective fluorescent sensor for homocysteine and cysteine

✍ Scribed by Tae-Ki Kim; Dong-Nam Lee; Hae-Jo Kim

• Book ID: 104095495
• Publisher: Elsevier Science
• Year: 2008
• Tongue: French
• Weight: 282 KB
• Volume: 49
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.06.003

✦ Synopsis

A new fluorescent sensor (1) based on a coumarin was synthesized for the selective detection of homocysteine (Hcy) and cysteine (Cys). The chemosensor has shown a selective response to Hcy or Cys over other various amino acids via a ring formation of thiazinane or thiazolidine. When Hcy or Cys was added, the fluorescent intensity of 1 was completely quenched through a photo-induced electron transfer with the sensitivity of sub-millimolar concentration.