Highly selective addition reaction of organotitaniums with Garner's aldehyde. Easy preparation of optically active allylic, allenylic, homoallylic and homopropargylic alcohols

✍ Scribed by Christophe Delas; Sentaro Okamoto; Fumie Sato

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 66 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)00783-9

✦ Synopsis

Organotitanium complexes 3-5 prepared from a Ti(O-i-Pr) 4 /2/i-PrMgX reagent (2) and the corresponding unsaturated compounds reacted with Garner's aldehyde (1) to provide anti-addition products highly predominantly, thus allowing an easy access to a variety of optically active anti-1,2-aminoalcohol derivatives.