Highly regio- and stereo-controlled Pd(0)-catalyzed nucleophilic substitution reaction for the synthesis of optically active γ-fluoroalkylated allylic alcohols

✍ Scribed by Tsutomu Konno; Takashi Ishihara; Hiroki Yamanaka

• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 87 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)01485-4

✦ Synopsis

Pd(0)-catalyzed nucleophilic substitution reaction of optically active a-(fluoroalkyl)allyl mesylates with various types of carboxylates proceeded regioselectively to afford the corresponding chiral g-fluoroalkylated allylic alcohol derivatives in excellent yields without any loss of optical purities.