Highly Fluorescent Silica-Coated Bismuth-Doped Aluminosilicate Nanoparticles for Near-Infrared Bioimaging
✍ Scribed by Hong-Tao Sun; Junjie Yang; Minoru Fujii; Yoshio Sakka; Yufang Zhu; Takayuki Asahara; Naoto Shirahata; Masaaki Ii; Zhenhua Bai; Ji-Guang Li; Hong Gao
- Book ID
- 104593526
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 656 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1613-6810
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✦ Synopsis
For in vivo and deep-tissue imaging, near-infrared (NIR)emitting nanoparticles (NPs) offer many advantages over visible-light-emitting NPs because the optical absorption and light scattering of biological media and tissue autofl uorescence are minimal in the NIR region of the electromagnetic spectrum. [ 1 ] Up to now, a wide array of novel nanomaterials, including quantum dots (QDs), organic dyes, and dyedoped or undoped inorganic NPs, have been developed for bioimaging. [1][2][3][4][5][6] For instance, QDs modifi ed with tumortargeting ligands have been successfully used as in vivo cancertargeted imaging agents of living animals. [ 2 b] Unfortunately, most QDs contain extremely toxic elements such as cadmium and lead, and dyes are easily photobleached, which makes it rather diffi cult to use them for in vivo imaging in humans. [1][2][3][4][5][6][7] Consequently, the development of nontoxic and biocompatible NPs emitting in the NIR region, especially in the second biological window (1.0-1.4 μ m), is urgently needed. [ 1 ] Bismuth, atomic number 83 and the heaviest stable element in the periodic table, was established as an element in 1739 by Potts and Bergmann. [ 8 a] Bismuth has long been associated with medicine. [ 8 b] The earliest use of bismuth compounds in medicine appears to have been in the Middle Ages. Since