✦ LIBER ✦

Highly Enantioselective Synthesis of α-Amino Acid Derivatives by an NHC-Catalyzed Intermolecular Stetter Reaction

✍ Scribed by Dr. Thierry Jousseaume; Nathalie E. Wurz; Prof. Dr. Frank Glorius

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 345 KB
Volume: 50
Category: Article
ISSN: 0044-8249
DOI: 10.1002/anie.201006548

No coin nor oath required. For personal study only.

✦ Synopsis

Dedicated to Professor Ronald Breslow on the occasion of his 80th birthday Scheme 1. Chiral NHC- [11,12] or enzyme-catalyzed [13] intermolecular asymmetric Stetter reactions. EWG = electron-withdrawing group, Ar = aromatic group, Het = heteroaromatic group, R = rest. Scheme 2. Proposed reaction pathway for an intermolecular enantioselective Stetter reaction.

📜 SIMILAR VOLUMES

Proline-Catalyzed Asymmetric Mannich Rea

Proline-Catalyzed Asymmetric Mannich Reactions: The Highly Enantioselective Synthesis of Amino Acid Derivatives and 1,2-Amino Alcohols

✍ Scott M. Sheehan 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 53 KB 👁 1 views

Enantioselective Synthesis of α-Fluorina

Enantioselective Synthesis of α-Fluorinated β-Amino Acid Derivatives by an Asymmetric Mannich Reaction and Selective Deacylation/Decarboxylation Reactions

✍ Yuanhang Pan; Yujun Zhao; Ting Ma; Yuanyong Yang; Hongjun Liu; Zhiyong Jiang; Ch 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB 👁 1 views

Powerful probes for revealing the workings of biological systems can be prepared through the judicious replacement of hydrogen atoms with fluorine. [1] The C À F bond has a significant effect on the reactivity, stability, and bioavailability of molecules. [2] Thus, there is a strong demand for a wid

Proline-Catalyzed Highly Enantioselectiv

Proline-Catalyzed Highly Enantioselective and anti-Selective Mannich Reaction of Unactivated Ketones: Synthesis of Chiral α-Amino Acids

✍ Björn T. Hahn; Roland Fröhlich; Klaus Harms; Frank Glorius 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 338 KB 👁 1 views

ChemInform Abstract: Enantioselective Sy

ChemInform Abstract: Enantioselective Synthesis of α-Fluorinated β-Amino Acid Derivatives by an Asymmetric Mannich Reaction and Selective Deacylation/Decarboxylation Reactions.

✍ Yuanhang Pan; Yujun Zhao; Ting Ma; Yuanyong Yang; Hongjun Liu; Zhiyong Jiang; Ch 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 66 KB

Asymmetric Catalytic Mannich Reactions C

Asymmetric Catalytic Mannich Reactions Catalyzed by Urea Derivatives: Enantioselective Synthesis of β-Aryl-β-amino Acids.

✍ Anna G. Wenzel; Eric N. Jacobsen 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 185 KB

## Abstract For Abstract see ChemInform Abstract in Full Text.

Highly Enantioselective Synthesis of β-A

Highly Enantioselective Synthesis of β-Amino Acid Derivatives by the Lewis Base Catalyzed Hydrosilylation of β-Enamino Esters

✍ Hong-Jie Zheng; Wen-Bing Chen; Zhi-Jun Wu; Jin-Gen Deng; Wen-Qing Lin; Wei-Cheng 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 249 KB

Optically active b-amino acids are very important chiral building blocks for the synthesis of b-peptides, b-lactams, natural products, and physiologically active substances. [1] Therefore, efficient methods for the synthesis of optically active b-amino acids would be of great value for drug discover