Highly Enantioselective Proline-Catalysed Direct Aldol Reaction of Chloroacetone and Aromatic Aldehydes
✍ Scribed by Ángel Martínez-Castañeda; Belén Poladura; Dr. Humberto Rodríguez-Solla; Dr. Carmen Concellón; Dr. Vicente del Amo
- Book ID
- 112020000
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 192 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0947-6539
No coin nor oath required. For personal study only.
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## Abstract The CoCl~2~/L‐proline (1:2) system was found to be an excellent catalyst for direct aldol reactions. Excellent yields (up to 93 %) and a significant improvement in diastereoselectivity (__anti__/__syn__ up to 45:1) as well as enantioselectivity (up to more than 99 % __ee__) compared wit