Highly Enantioselective Palladium-Catalyzed Ene-Type Cyclization of a 1,6-Enyne
β Scribed by Manabu Hatano; Masahiro Terada; Koichi Mikami
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 241 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0044-8249
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## Abstract A novel asymmetric catalysis __via__ a palladium(II)/palladium(IV) cycle has been developed by utilizing a chiral spiro bis(isoxazoline) ligand (SPRIX). Intramolecular chlorinative cyclization of 1,6βenynes catalyzed by a palladiumβSPRIX complex proceeded enantioselectively to afford Ξ±β
TbtCHSe, 4 was prepared by the reaction of TbtCHN, [9] with (C,H,),TiSe,[li~ in the presence of a catalytic amount of CuCl at room temperature. 4 was obtained as an inseparable mixture of compounds with different numbers of selenium atoms. the average number of which was determined to be 5.1 by elem