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Highly Enantioselective Michael Addition of Nitroalkanes to Chalcones Using Chiral Squaramides as Hydrogen Bonding Organocatalysts

✍ Scribed by Yang, Wen; Du, Da-Ming


Book ID
121204641
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
314 KB
Volume
12
Category
Article
ISSN
1523-7060

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A new efficient catalyst system for the asymmetric addition of acetylacetone to nitroolefins using a chiral bifunctional organocatalyst bearing multiple hydrogen-bonding donors was developed. When using the organocatalyst 2c derived from natural cinchona alkaloid in optimal conditions, up to 98% che