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Highly Enantioselective Complex-Catalyzed Reduction of Ketones— Now with Purely Aliphatic Derivatives Too

✍ Scribed by Volker Fehring; Rüdiger Selke


Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
116 KB
Volume
37
Category
Article
ISSN
0044-8249

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Enantioselective reduction of ketones wi
✍ Dong-Sheng Lee 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 150 KB

## Abstract In the presence of tridentate chiral ligand **4e**, 99% e.e. value was obtained by asymmetric reduction of ethyl benzoylacetate with borane in toluene at 25°C. Various ligands and reaction conditions were investigated to develop a reasonable mechanism that explains the experimental outc