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Highly Enantioselective Catalytic Michael Reaction of α-Substituted Malonates Using La-Linked-BINOL Complex in the Presence of HFIP (1,1,1,3,3,3-Hexafluoroisopropanol).

✍ Scribed by Ryo Takita; Takashi Ohshima; Masakatsu Shibasaki


Book ID
101936159
Publisher
John Wiley and Sons
Year
2010
Weight
37 KB
Volume
33
Category
Article
ISSN
0931-7597

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Highly enantioselective catalytic Michae
✍ Ryo Takita; Takashi Ohshima; Masakatsu Shibasaki 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 133 KB

A catalytic asymmetric Michael reaction of a-substituted malonates with broad generality was developed using the La-linked-BINOL complex. To enhance the reactivity of unreactive a-substituted malonates, we examined the effects of concentration and additives; 1.0 M was the best concentration and HFIP