Highly enantioselective catalytic Michae
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Ryo Takita; Takashi Ohshima; Masakatsu Shibasaki
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Article
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2002
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Elsevier Science
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French
⚖ 133 KB
A catalytic asymmetric Michael reaction of a-substituted malonates with broad generality was developed using the La-linked-BINOL complex. To enhance the reactivity of unreactive a-substituted malonates, we examined the effects of concentration and additives; 1.0 M was the best concentration and HFIP