Enantioselective Copper-Catalyzed 1,4-Addition of Organozinc Reagents to Enones Using Chiral Oxazoline-Phosphite Ligands. -The enantioselective 1,4-addition of organozinc reagents to α,β-unsaturated ketones in the presence of chiral P,N-ligands (I) with a binaphthyl phosphite group and an oxazoline
✦ LIBER ✦
Highly Enantioselective 1,4-Addition of Diethyl Phosphite to Enones Using a Dinuclear Zn Catalyst
✍ Scribed by Depeng Zhao; Ye Yuan; Albert S. C. Chan; Rui Wang
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 211 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0947-6539
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## Abstract 2‐Hydroxy‐2′‐alkylthio‐1,1′‐binaphthyl compounds are catalytic promoters of the 1,4‐addition of AlMe~3~ to linear aliphatic enones in THF at −40 to −48 °C in the presence of [Cu(MeCN)~4~]BF~4~. At ligand loadings of 5–20 mol %, enantioselectivities of 80–93 % are realised for most subst
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