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Highly Enantio- and Diastereoselective Organocatalytic Asymmetric Domino Michael—Aldol Reaction of β-Ketoesters and α,β-Unsaturated Ketones.

✍ Scribed by Nis Halland; Pompiliu S. Aburel; Karl Anker Joergensen


Publisher
John Wiley and Sons
Year
2004
Weight
183 KB
Volume
35
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

For Abstract see ChemInform Abstract in Full Text.


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Highly Enantio- and Diastereoselective O
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## Abstract A chiral imidazolidine catalyst was shown to catalyze the highly enantio‐ and diastereoselective domino Michael‐aldol reaction of β‐diketone and β‐ketosulfone derivatives with α,β‐unsaturated ketones to form optically active cyclohexanones having three or four contiguous chiral centers.

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