✍ Scribed by Ji Young Kim; Seok Hwan Kim; Sukbok Chang
No coin nor oath required. For personal study only.
Using ynamides as one of the reacting components, the Cu-catalyzed three-component reaction of sulfonyl or phosphoryl azides and amines affords a-amino amidines in high yields under mild conditions. Synthetic utility of the produced compounds was demonstrated in the diastereoselective alkylation of a-amino amidines bearing a chiral oxazolidinone moiety. It was also shown that a-amino imidates could be readily prepared by employing alcohols instead of amines.
📜 SIMILAR VOLUMES
Three-component reactions of aldehydes, amines, and diethyl phosphite catalyzed by FeCl 3 in EtOH or under solvent-free and mild conditions afforded the corresponding α-amino phosphonates in excellent yields.
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