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Highly efficient synthesis of 3-indolyl-substituted phthalides via Friedel–Crafts reactions in water

✍ Scribed by Hua Lin; Xing-Wen Sun

Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
177 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis

An efficient and simple method for the synthesis of 3-indolyl-substituted phthalides via Friedel-Crafts reaction of indoles with 2-formylbenzoic acids in pure water has been developed. The reaction affords a wide range of 3-indolyl-substituted phthalides in good to excellent yields.

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