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Highly efficient preparation of carbon-14 labeled, auxin herbicide 4-amino-3,5,6-trichloropicolinic acid

✍ Scribed by Norman R. Pearson; Tom S. Lardie

Publisher
John Wiley and Sons
Year
2006
Tongue
French
Weight
118 KB
Volume
49
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A highly efficient, seven‐step route has been developed for the preparation of 2,6‐[^14^C~2~]‐4‐amino‐3,5,6‐trichloropicolinic acid ([^14^C~2~]‐1, 2,6‐[^14^C~2~]‐picloram) from 2,6‐[^14^C~2~]‐pentachloropyridine. The method involves the stepwise, highly selective and high yield introduction of amino and carboxylic acid groups to the 4‐ and 2‐positions, respectively, of pentachloropyridine affording [^14^C~2~]‐1 in an overall radiochemical yield of >70% with the use of only one formal purification step. Copyright © 2006 John Wiley & Sons, Ltd.

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